Frankenstein believes throughout his life that he is better (smarter, more cunning, in more control, stronger) than his creation. This turns out to be a gross misread on his part that costs him Elizabeth’s life.
Once the monster is given life, Frankenstein cannot put the cat back in the bag. He didn’t fully understand the consequences of his creation, implying that he thought he’d be in greater control of the situation after the fact.
Knowledge is a double-edged sword
In Part 1, Frankenstein’s pursuit of knowledge draws him away from those he loves, brings him to the brink of health crises, and has him procure a creation he ultimately regrets. In Part 2, the monster has a similar track where his acquisition of knowledge removes his naivety of the world, and he can see evil done to the family he watches over.